http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110128339-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2602-08 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C271-24 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C269-04 |
| filingDate | 2019-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110128339-B |
| titleOfInvention | Synthetic method and intermediate for indacaterol and salt derivative thereof |
| abstract | The invention belongs to the technical field of drug synthesis, and particularly relates to a method for synthesizing indacaterol and salt derivatives thereof and an intermediate for synthesis. The method for synthesizing indacaterol takes a compound with a general formula IV and a compound with a formula V as raw materials, and obtains a compound with a formula I through amine alkylation and deprotection in one pot, wherein the reaction equation is as follows: wherein R is a silyl protecting group. According to the technical scheme provided by the invention, through carrying out Boc protection on amino, multi-alkylation on amino is ingeniously avoided, under the condition that both hydroxyl and amino are properly protected, alkylation reaction effectively avoids generation of byproducts, and deprotection of hydroxyl and amino can be directly carried out after alkylation reaction, so that multi-step reaction is completed in one reactor, the intermediate purification and separation process is saved, the reaction yield is improved to the greatest extent, and the production cost is reduced. |
| priorityDate | 2019-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 77.