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filingDate 2019-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2af65a1c6853cf0f6cfbb23de6b3822c
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publicationDate 2019-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-110128268-A
titleOfInvention A kind of method of continuous production ibuprofen ester
abstract The present invention relates to a kind of methods of continuous production ibuprofen ester, belong to field of medicine and chemical technology;Include the following steps;One, the washing ketal that condensation reaction generates, by being pumped into level-one rearrangement reactor, catalyst squeezes into level-one rearrangement reactor by pumping, and the laggard rearrangement reaction of solvent is added;Two, rearrangement reaction successively carries out in multiple concatenated continuous rearrangement reactors, and reaction of high order is overflow discharging;Three, the gas phase of reaction of high order enters condenser, and condensed material enters return tank;The process that the solvent having more enters condensation reaction from return tank side overflow.Four, rearrangement solution is discharged by afterbody rearrangement reactor overflow, into subsequent processing;The reaction time is shortened, the generation of rearrangement process side reaction is reduced, the yield of ibuprofen ester is improved to 95% or more.
priorityDate 2019-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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