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filingDate 2019-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2021-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2021-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-110124112-B
titleOfInvention Halloysite and arginine-based modified polyester urea-urethane composite material and preparation and application thereof
abstract The invention belongs to the technical field of tissue engineering materials, and discloses a halloysite and arginine modified polyester urea-urethane composite material, and a preparation method and an application thereof. The method comprises the following steps: 1) under the conditions of inert atmosphere and stirring, carrying out prepolymerization reaction on polycaprolactone diol and hexamethylene diisocyanate under the action of an initiator, cooling to 40-70 ℃, adding an L-arginine-1, 8-octanediol ester solution, continuously reacting for 5-10 h, diluting, dialyzing, and freeze-drying to obtain a polyester urea-urethane material; 2) dissolving the polyester urea-urethane material in an organic solvent, adding the halloysite nanotube, uniformly dispersing, and forming a film to obtain the composite material. The method is simple, and the prepared composite material has good physical and chemical properties and biological properties, can promote the generation of new bones and the repair of bone defects and realize self degradation; is used in the field of bone tissue engineering materials.
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