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filingDate 2019-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2021-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2021-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-110124035-B
titleOfInvention Gold nanorod/calcium carbonate nanoparticle material, and preparation method and application thereof
abstract The invention relates to the field of new biomedical materials, in particular to a gold nanorod/calcium carbonate nanoparticle material, and a preparation method and application thereof. The gold nanorod/calcium carbonate nanoparticle material comprises a polymer-modified gold nanorod and a polymer-modified calcium carbonate nanoparticle; the polymer is polyethyleneimine and polyethylene glycol. The gold nanorod/calcium carbonate nanoparticle material provided by the invention basically has no toxic or side effect, and has a better photoacoustic imaging effect. After the polymer modified gold nanorods and the polymer modified calcium carbonate nanoparticles are respectively administrated through tail veins, the polymer modified calcium carbonate nanoparticles reach a tumor region, can generate carbon dioxide, and achieve the purpose of enhancing photoacoustic imaging, thereby being capable of monitoring in real time; the gold nanorods modified by the polymer reach the tumor region, and can be used for effective photothermal treatment under the guidance of photoacoustic imaging, so that diagnosis and treatment are integrated.
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