http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110117580-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-93 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y601-01 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-00 |
| filingDate | 2018-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110117580-B |
| titleOfInvention | Seleno-tyrosine translation system and application thereof |
| abstract | The present invention relates to an aminoacyl-tRNA synthetase mutant, which is an orthogonal aminoacyl-tRNA synthetase comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 4 or a conservative variant or homologue thereof having the same enzymatic activity. The present invention also provides a seleno-tyrosine translation system comprising: (i) seleno-tyrosine; (ii) the orthogonal aminoacyl-tRNA synthetase; (iii) an orthogonal tRNA, wherein said orthogonal aminoacyl-tRNA synthetase preferentially aminoacylates said orthogonal tRNA with seleno tyrosine; and (iv) a nucleic acid encoding a protein of interest, wherein the nucleic acid comprises at least one selector codon that is specifically recognized by the orthogonal tRNA. The invention also provides a method for designing and modifying protease by utilizing the seleno-tyrosine translation system, and the protease produced by the method. |
| priorityDate | 2018-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 331.