http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110117309-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2410-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06026 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-68 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-062 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
| filingDate | 2019-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110117309-B |
| titleOfInvention | Isomer impurity in a kind of enalapril maleate crude drug and its synthetic method |
| abstract | The invention provides an isomer impurity in enalapril maleate crude drug and a preparation method thereof. Condensation and acylation reaction of N-tert-butoxycarbonyl-D-alanine (compound Ⅰ) (Ⅰ) and D-proline benzyl ester (Ⅱ) to obtain intermediate compound III, and then de-Boc protection to obtain intermediate compound Ⅳ, intermediate Ⅳ and ethyl 2-oxo-4-phenylbutyrate (Ⅴ) were reductively aminated to obtain compound Ⅵ, and compound Ⅵ was hydrogenated to remove the benzyl group to obtain the enalapril enantiomer (TM1 ) and diastereoisomers (TM2) mixture, and then separated by preparative chromatography to obtain enalapril enantiomers (TM1) and diastereomers (TM2). |
| priorityDate | 2019-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 157.