| abstract |
The present invention relates to salts of cyclin-dependent kinase inhibitors and crystal forms thereof. The present invention relates to a kind of (4-(cyclopropylamino)piperidin-1-yl)(6-((5-fluoro-4-(1-isopropyl-2-methyl) having a structure of general formula (I) Base-1H-benzo[d]imidazole-6-yl)pyrimidin-2-yl)amino)-2-picoline-3-yl)methanone and its salt preparation method and application and containing therapeutically effective amount of A pharmaceutical composition of the salt. CDK4/6 highly selective inhibitors can be clinically used to treat HR+/HER2‑ breast cancer patients. In addition, it can also be used for the treatment of non-small cell lung cancer, head and neck cancer, brain tumor, melanoma, etc., wherein each substituent in the general formula (I) is the same as defined in the description. |