http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110108780-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N27-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6851 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N1-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N1-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N27-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
| filingDate | 2019-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110108780-B |
| titleOfInvention | Application of 3-hydrazinobenzoic acid-derivatized glucan in MALDI-TOF-MS (matrix-assisted laser Desorption-time of flight-Mass Spectrometry) |
| abstract | The invention belongs to the field of mass spectrometry detection, and particularly discloses application of reaction matrix 3-hydrazinobenzoic acid-derivatized glucan in MALDI mass spectrometry mass calibration. 3-hydrazinobenzoic acid and the hemiacetal at the end of reducing sugar are reacted to generate hydrazone, the reaction has high derivatization efficiency, and the target plate is utilized for online derivatization, so that the operation is simple and convenient. With this derivatization strategy, the derivatized product can be detected in both positive and negative ion modes. And the carboxylate radical in the 3-hydrazinobenzoic acid obviously improves the ionization efficiency of the reducing sugar in the negative ion mode. The invention uses 3-hydrazinobenzoic acid derived glucan as a mass calibrator of MALDI mass spectrum, the mass difference between adjacent signal peaks is 162Da, corresponding to a glucose residue, and the accurate calibration under positive and negative ion modes is realized. |
| priorityDate | 2019-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 39.