http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110105290-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-47 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-47 |
| filingDate | 2019-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110105290-B |
| titleOfInvention | Preparation method of 5-fluorocytosine |
| abstract | The invention provides a preparation method of 5-fluorocytosine, which is characterized by comprising the following steps: adding an organic solvent, fluoroacetonitrile, ethyl formate and organic base into a high-pressure kettle, heating to react in a preset gas environment, and then decompressing and cooling to obtain a first reaction liquid containing an intermediate 1; adding an alcoholic solution of hydrogen chloride into a reaction kettle, cooling, adding a first reaction solution for reaction to obtain a second reaction solution, adding water into the second reaction solution, adjusting the pH value to 6-8, standing to obtain a first organic layer, and distilling the first organic layer to obtain an intermediate 2; and step three, carrying out an ammonia-aldehyde condensation reaction on the intermediate 2 and urea to obtain a 5-fluorocytosine crude product. The method has the advantages of simple synthesis process, less total steps required by the reaction, higher total yield, high reaction safety, improved production efficiency and reduced production cost. |
| priorityDate | 2019-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 67.