http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110105283-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f416f6c697875fea7151d05a201b591c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4164 |
| filingDate | 2019-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bed0951c0b6908f2beec515be25757de http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f7a9c91296b50d4a95b2a655cbc72c54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_41a67432e7087f8e2d5585c0fac452a5 |
| publicationDate | 2019-08-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110105283-A |
| titleOfInvention | A kind of celecoxib derivative and its preparation method and use |
| abstract | The invention discloses a celecoxib derivative having the structure of formula (I) or a pharmaceutically acceptable salt thereof, as well as a preparation method and application thereof. The compound disclosed in the present invention can be used as a substitute for celecoxib, and it can exist in the form of hydrate or solvent, which solves the problem that the existing celecoxib drug is poorly water-soluble, with poor dissolution and low absorption in vivo The structure-activity relationship of celecoxib is analyzed and studied, and it is confirmed that the celecoxib disclosed in the present invention is better than the structural modifications such as nitrogen-containing derivatives, sulfur-containing derivatives, oxygen ethers, esterification of alcohol hydroxyl functional groups, etc. Sulfonamide derivatives with better medicinal biological activity. |
| priorityDate | 2019-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 67.