http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110101676-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_11d18be396970ff40fd4b0d214c8dc5b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2095 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2063 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4985 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4985 |
| filingDate | 2019-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_829d9e744caad9ee90738a31aa0f86d9 |
| publicationDate | 2019-08-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110101676-A |
| titleOfInvention | Preparation method of pharmaceutical intermediate pyrrolidone compounds |
| abstract | The present invention provides a method for preparing a pharmaceutical intermediate pyrrolidone compound, comprising the following steps: S1: preparing a preparation material, wherein the preparation material comprises the following 3.5-18.5 parts by weight of raw material zopiclone, 9 parts by weight of hydroxyethyl cellulose -15 parts, 55-78 parts of microcrystalline cellulose, 5-15 parts of low-substituted hydroxypropyl cellulose, 0.5-2.5 parts of sweetener, 0.5-1 part of lubricant, 0.5-1 part of glidant; S2: the The main drug zopiclone is suspended in an aqueous solution of hydroxyethyl cellulose, and then spray-dried to form pretreated main drug granules; S3: The pretreated main drug granules and microcrystalline cellulose, low-substituted hydroxypropyl cellulose, sweet taste It is prepared by sieving and tableting after mixing the agent, lubricant and glidant. The invention can quickly disintegrate in a short time, is convenient to take, effectively improves the drug efficacy (bioavailability) of the tablet, and plays a role quickly. |
| priorityDate | 2019-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.