| abstract |
The present invention provides a benzosix six-membered nitrogen heterocyclic compound and a preparation method and application thereof, wherein the benzos six-membered nitrogen heterocyclic compound has a structure as shown in formula I or formula II; A nitrogen-membered heterocyclic compound can effectively inhibit the bromodomain receptor and effectively inhibit the proliferation of cancer cells. Compared with the existing reported structure types, its binding mode is different and has higher inhibitory activity. It can be used as a drug for treating cancer, a drug for cell proliferation disorders, a drug for inflammatory diseases and autoimmune diseases, a drug for sepsis, and a drug for viral infection, and has good application prospects and high application value. |