http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110090225-B

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filingDate 2019-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2021-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2021-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-110090225-B
titleOfInvention Edaravone sodium chloride injection and preparation method thereof
abstract The invention relates to an edaravone sodium chloride injection and a preparation method thereof. 100ml of the injection comprises: 20-40mg of edaravone, 0.6-1.0g of sodium chloride, 150mg of propylene glycol 100, 2.5-3.5g of vitamin C and 0.3-1.0g of sodium bicarbonate, and the pH value is adjusted to 3.5-5.0. The preparation process of the injection comprises the following steps: preparing liquid, filtering, filling, capping, sterilizing and performing light inspection; the liquid preparation adopts a two-step preparation mode, and the preparation process adopts low-temperature preparation. The method is simple to operate and low in cost, and the prepared edaravone sodium chloride injection has good medicine stability, few side effects, high patient medication compliance and high safety, effectively reduces the generation of impurities, is used for improving neurological symptoms, daily life activity and dysfunction caused by acute cerebral infarction, and can effectively prevent and treat brain injury.
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