| abstract |
The present invention relates to methods of olaparib. 2-(2-(4-fluoro-3-carboxyphenyl) acetyl) benzoate reacts with hydrazine reagent to obtain 2-fluoro-5-((4-oxo-3,4-dihydrophthalein oxazin-1-yl)methyl)benzoic acid compound, then 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid and 1-cyclopropane The preparation of olaparib is achieved by the condensation reaction of carbamoylpiperazine. In addition, 2-(2-(4-fluoro-3-carboxyphenyl) acetyl) benzoate first undergoes condensation reaction with 1-cyclopropylformylpiperazine and then undergoes chemical reaction with hydrazine reagent to complete Ola Preparation of pani. |