| abstract |
The invention discloses a sulfonamide compound whose parent nucleus is tetrahydroquinoline and a preparation method and application thereof. The sulfonamide compound whose parent nucleus is tetrahydroquinoline provided by the invention has novel structure and simple preparation method, can specifically inhibit the activation of NLRP3 inflammasome and reduce the mature secretion of interleukin IL-1β, thereby reducing inflammatory damage, Improve the inflammatory microenvironment, have significant anti-inflammatory activity, and have no obvious toxicity to THP-1 cells. The compounds of the present invention can be prepared as anti-inflammatory drugs and used for the treatment of inflammation-related diseases, including cold pyridine-related periodic syndrome, inflammatory bowel disease, chronic obstructive pulmonary disease, diabetes, rheumatoid arthritis, rheumatoid Arthritis, gout, non-alcoholic fatty liver disease, chronic kidney disease, atherosclerosis, neurodegenerative diseases, etc. |