| abstract |
The present disclosure provides a nano-assembly based on an immune checkpoint inhibitor, a preparation method and an application thereof, including a polymer, a chlorin-grafted hyaluronic acid and a PD-L1 monoclonal antibody, and the polymer has a structural formula of The number-average molecular weight of the polymer is 2000-6000, and the ratio of m to n is 1:8-15. The nano-assembly provided by the present disclosure can realize the integrated treatment of enhanced antigen presentation stage, lymphocyte activation, proliferation and differentiation stage and tumor clearance. |