http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110054541-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-05 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C41-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C253-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C201-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C5-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C41-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C15-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C205-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C201-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C205-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C43-205 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C253-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-12 |
| filingDate | 2019-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110054541-B |
| titleOfInvention | Preparation method of deuterated aromatic compound |
| abstract | The invention discloses a preparation method of a deuterated aromatic compound, and particularly relates to a method for preparing a complex deuterated aromatic compound by a one-pot method, which combines palladium-catalyzed carbon-halogen bond reduction reaction with participation of deuterium anions and palladium-catalyzed coupling reaction with participation of bromides, takes halogenated aromatic hydrocarbon and brominated alkane as starting raw materials, sodium deuterated formate as a deuterated reagent, N, N-dimethylformamide as a solvent, a metal palladium complex as a catalyst, and organic phosphine as a ligand, and fully reacts at 30-100 ℃ under the protection of inert gas to synthesize a target compound. Compared with the traditional deuteration method, the method has the following advantages: the method has mild conditions, starts from simple and easily-obtained raw materials, directly obtains the complex deuterated compound by one step, and avoids the traditional multistep synthesis method; expensive deuterated reagents are avoided to be used as solvents in the reaction process, so that the production cost is reduced; the deuteration rate of the target product deuterated aromatic compound is more than 98 percent. |
| priorityDate | 2019-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 116.