http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110051857-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9353da21ba23e86e687a465920a68849 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6923 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2019-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6c95aaccfa8a1beb6654815c6632cebc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6c30fd72c17b1bb4acaf7bd6754d6bc6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e2ddfc3ee569a2ca201735472ce2123e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_59d5ba4022191a9b4fa2cd723ce829c3 |
| publicationDate | 2019-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110051857-A |
| titleOfInvention | A kind of preparation method and application of bimetallic doped multifaceted degradable mesoporous silica nanoparticles |
| abstract | The invention discloses a preparation method and application of bimetallic doped multifaceted degradable mesoporous silica nanoparticles. The invention adopts an improved sol-gel method to prepare multifaceted degradable mesoporous silica nanoparticles doped with two metal elements. Silicon oxide nanoparticles, the prepared nanoparticles have a multi-faceted structure in which circles and ellipses are connected, and two metal elements are distributed on two sides respectively. Drugs are loaded in mesoporous channels, and they coordinate with metals to form pH-responsive coordination bonds. Under acidic conditions, the coordination bonds are broken to release drugs, while under neutral conditions, drugs are stably loaded. Due to the metal doping and the mesoporous silica structure, the biodegradability of mesoporous silica is improved, so that the nanoparticles can be degraded in cells and release metal ions, and these metal ions can catalyze Fenton and Fen-like Tonic reaction, generating reactive oxygen species, and activating the ferroptosis pathway, and finally kill tumor cells efficiently. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113618079-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110591110-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111137899-A |
| priorityDate | 2019-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 118.