| abstract |
The present disclosure generally relates to compositions comprising cross-linked cationically bound polymers comprising carboxylic acid groups and pKa reducing groups, including, for example, electron withdrawing substituents such as halogen atoms (eg, fluorine), and a base. A monomer, wherein the polymer optionally contains less than about 20,000 ppm of non-hydrogen cations, and wherein the base is sufficient to provide from about 0.2 equivalents to about 0.95 equivalents per equivalent of carboxylic acid groups in the polymer amount of base present. The present disclosure also relates to methods of making such compositions and methods of using such compositions to treat various diseases or conditions. |