abstract |
The present invention relates to pyridine N-oxide derivatives and their preparation method and application. In particular, the present invention relates to the compound represented by the general formula (I), its preparation method and the pharmaceutical composition containing the compound, and its use as a BRD4 inhibitor in the treatment of cancer, inflammation, chronic liver disease, diabetes, cardiovascular disease and AIDS and other related diseases, wherein each substituent in the general formula (I) is the same as the definition in the specification. |