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filingDate 2019-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2021-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2021-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-110038167-B
titleOfInvention A biomimetic glycosylated mineralized collagen/glycosylated chitosan/PLGA composite bone tissue engineering scaffold and preparation method thereof
abstract The invention relates to a biomimetic glycosylated mineralized collagen/glycosylated chitosan/PLGA composite bone tissue engineering scaffold and a preparation method thereof. The invention uses glycosylated mineralized collagen, glycosylated chitosan and PLGA as raw materials to prepare porous composite bone tissue engineering scaffold materials, and makes up for the poor formability, low mechanical strength and weak cell adsorption of a single material by adjusting the composition ratio of the raw materials. Shortcomings. PLGA has good biocompatibility, non-toxicity and good molding properties. The three-dimensional hole network structure prepared by combining glycosylated mineralized collagen, glycosylated chitosan and PLGA by thermally induced phase separation has the same properties as natural PLGA. The extremely similar nanostructure of bone is conducive to the adhesion, proliferation and differentiation of cells on the surface of the scaffold material, and a certain roughness and porosity are also conducive to the growth of new bone tissue into the surface of the implant, and promote the implant/host tissue Osseointegration process at the interface.
priorityDate 2019-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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