| abstract |
The present invention relates to the field of antimicrobial agents. In particular, the present invention relates to polypeptides comprising a peptidoglycan hydrolase sequence and a peptide sequence heterologous to the peptidoglycan hydrolase, wherein the heterologous peptide sequence comprises 16, 17, 18, 19 or 20 amino acids in length specific sequence motifs. The present invention also relates to corresponding nucleic acids, vectors, phages, host cells, compositions and kits. The present invention also relates to the use of said polypeptides, nucleic acids, vectors, phages, host cells, compositions and kits in methods for the treatment of the human or animal body by surgery or therapy or in diagnostic methods carried out on the human or animal body use. Polypeptides, nucleic acids, vectors, phages, host cells, compositions and kits according to the invention can also be used as antimicrobial agents or as disinfectants, eg in food or feed, in cosmetics. |