http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110028487-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D335-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D335-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-14 |
| filingDate | 2019-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110028487-B |
| titleOfInvention | Preparation method of thiochromanone compound |
| abstract | The invention provides a preparation method of a thiochromanone compound, which comprises the following steps: reacting a compound shown in a formula (II) with an alkyne compound shown in a formula (III) in the presence of a nickel catalyst to obtain a compound shown in a formula (I); wherein R is 1 、R 2 And R 3 Each independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted acyl; x is selected from S, SO or SO 2 . Compared with the prior art, the method has the advantages that the nickel catalyst is used for catalyzing the benzenesulfonyl anhydride derivative and the alkyne compound to perform the deoxidation reaction, so that the thiochromogen ketone compound is obtained, the operation is simple, the raw materials and the reagents are easy to obtain, the condition is mild, the catalytic system is green and environment-friendly, the product is easy to separate and purify, the method is suitable for synthesizing various types of thiochromogen ketone compounds, is particularly suitable for large-scale industrial production, and the high-purity thiochromogen ketone compound can be prepared efficiently with high yield. |
| priorityDate | 2019-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.