http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110016029-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2019-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110016029-B |
| titleOfInvention | Preparation method of 3-fluoro-1H-pyrrolo [2,3-b ] pyridine-2-carboxylic acid |
| abstract | The invention discloses a preparation method of 3-fluoro-1H-pyrrolo [2,3-b ] pyridine-2-carboxylic acid, which comprises the following steps: dissolving 3-fluoro-1H-pyrrolo [2,3-b ] pyridine in a solvent, and adding sulfonyl chloride compounds to react under an alkaline condition to obtain 3-fluoro-1R-pyrrolo [2,3-b ] pyridine; dissolving 3-fluoro-1R-pyrrolo [2,3-b ] pyridine in a solvent, and reacting with dry ice under an alkaline condition to obtain 3-fluoro-1R-pyrrolo [2,3-b ] pyridine-2-carboxylic acid; hydrolyzing the 3-fluoro-1R-pyrrolo [2,3-b ] pyridine-2-carboxylic acid in a solution at 0-30 ℃ under an alkaline condition to obtain the 3-fluoro-1H-pyrrolo [2,3-b ] pyridine-2-carboxylic acid. The preparation method for preparing the 3-fluoro-1H-pyrrolo [2,3-b ] pyridine-2-carboxylic acid only needs three steps of reaction, quickly and efficiently obtains the target product, does not need column chromatography purification of the reaction product, does not use high-risk reagents such as diazomethane and the like, and is suitable for large-scale industrial production. |
| priorityDate | 2019-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 84.