| abstract |
The invention discloses a method for synthesizing a high-selectivity luliconazole intermediate, which adopts (-)-diisopinepineyl chloride borane as a high-selectivity catalyst, and in a tetrahydrofuran reaction system, adopts low-temperature reduction to obtain (S) -2,2',4'-Trichlorophenethyl reaction solution, then through quenching, organic solvent extraction, drying and concentration to obtain the crude product of (S)-2,2',4'-Trichlorophenethyl alcohol; Finally, the alkane reagent is stirred and crystallized to obtain high-purity (S)-2,2',4'-trichlorophenethyl alcohol. The synthesis of the invention uses (-)-diisopinepineyl chloride borane as a catalyst, and has few steps, high synthesis efficiency, simple operation, low cost and high product selectivity. |