| abstract |
The invention discloses a kind of radioiodination two dimension palladium base probes and its preparation method and application, including two-dimentional palladium base nano material, PEG connection molecule, targeting group R and radioiodine, one end of PEG connection molecule has sulfydryl, the other end of PEG connection molecule has can modification group, one end of PEG connection molecule is connected by above-mentioned sulfydryl with two-dimentional palladium base nano material, the other end by can modification group with target group R be connected, radioiodine is directly marked in two-dimentional palladium base nano material.The present invention is based on binding forces strong between two-dimentional palladium base nano material and halide ion, multiple radioiodines can be carried on unit nano-carrier, have the characteristics that marked capacity is strong, the label time is short, label yield is high, it can be used without subsequent purification, be more conducive to the commercial applications and clinical expansion of marker. |