| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d3f99e9e5260c96e7d300f8bd8e33353 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-18434
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-18422
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-552
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-523 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-098
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-01 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-155
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-10 |
| filingDate |
2019-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a3554a4168f07f017f5bbed28e106c14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_490f42364ad22d8e0191e48b1a018101
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_615d1a6f7dabe13f7b1351532d8baf3e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_99950910580b0e9258b9185075785a4d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b40ef165d80ff8b0b15f13a8d679a62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_628bb4f10c5de982c62ad81320581900
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7d9ec9ab01e6f36cee4ddbe964763182
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_88586a147eeeaae829185a2ce52d2cef
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9dbbb3a70fd2b37980b49ddff87f16bd |
| publicationDate |
2019-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-110013547-A |
| titleOfInvention |
A strain of Brucella crassa with recombinant PPR virus H gene and a method for producing its vaccine |
| abstract |
The present invention relates to the construction of a strain of Brucella rough with H gene of recombinant Peste des petits ruminants virus and a vaccine thereof. In the present invention, the attenuated strain RA343 of the rough-type Brucella bovis is used as the parental strain, and the sucrose suicide plasmid is used as the carrier, and the H gene of the Peste des petits ruminants virus containing a specific promoter sequence is codon-optimized and then inserted into the Brucella without trace. In the bacterial genome, a recombinant Brucella RA343-PPRV-H strain capable of highly expressing the recombinant PPR virus H gene was successfully constructed. The recombinant strain not only retains the rough-type characteristics of the original parent strain RA343 and has good immune protection against brucellosis (brucellosis), but also can produce specific neutralization against PPR after immunizing animals with the recombinant strain Antibodies to achieve immune protection against Peste des petits ruminants. The vaccine prepared by using the recombinant vaccine strain can simultaneously achieve dual immune protection against brucellosis and Peste des petits ruminants after immunizing animals. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-116144601-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-116144601-B |
| priorityDate |
2019-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |