http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110003220-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-54 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C59-265 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-412 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-265 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-41 |
| filingDate | 2019-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-01-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-01-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110003220-B |
| titleOfInvention | Preparation method of tofacitinib citrate |
| abstract | The invention discloses citric acidA preparation method of tofacitinib. The method comprises the following steps: 1) carrying out desalting reaction on the compound shown in the formula II under an alkaline condition to obtain an intermediate shown in the formula III; 2) reacting an intermediate shown in a formula III, ethyl cyanoacetate and alkali in an inert atmosphere in the presence of an alkaline ionic liquid to obtain a reaction solution containing tofacitinib alkali; 3) and adding monohydrate citric acid into the reaction solution containing tofacitinib alkali to carry out salt forming reaction to obtain tofacitinib citrate. In the preparation process of the invention, a proper amount of [ Bmim ] is added]Im and a combination of triethylamine and pyridine in a specific ratio is selected as a base, and the ionic liquid is used as a solvent for the reaction on one hand and a catalyst on the other hand, so that the reaction can be promoted to be rapidly carried out, and meanwhile, the yield and the purity of the product are improved. |
| priorityDate | 2019-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 58.