http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110003218-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2019-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110003218-B |
| titleOfInvention | Preparation method of Allagliptin intermediate |
| abstract | The invention provides a preparation method of an Alalogliptin intermediate, which comprises the following steps: (1) performing Vilsmiere reaction on N, N-dimethylformamide (I) and acyl chloride to generate a Vilsmiere reagent, dropwise adding bromoacetic acid (II) into the Vilsmiere reagent, heating for reaction, and hydrolyzing to obtain diformylaldehyde (III); (2) dissolving diformylacetaldehyde (III) and 3-amino-5-methylpyrazole (IV) in an alcohol/sodium alkoxide system, heating, refluxing and stirring to generate 6-formaldehyde-2-methyl-pyrazolo [1,5-a ] pyrimidine (V); (3) oxidizing the 6-formaldehyde-2-methyl-pyrazolo [1,5-a ] pyrimidine (V) in strong alkali to generate 2-methyl-pyrazolo [1,5-a ] pyrimidine-6-carboxylic acid (VI). The invention simplifies the reaction steps, has simple and convenient operation, less three wastes and high yield. |
| priorityDate | 2019-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 79.