http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110003193-A

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filingDate 2019-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3576d8ddbbbafebb3563649c087c0c1d
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publicationDate 2019-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-110003193-A
titleOfInvention A kind of rivaroxaban that is easy to be pulverized and preparation method thereof
abstract The present invention relates to a method for preparing easily pulverized rivaroxaban. The method includes the steps of adding the crude rivaroxaban into a solvent, heating it up to make it completely dissolved, and then allowing it to stand for cooling and crystallization. By this method, rivaroxaban crystal grains with suitable particle size and uniform particle size can be obtained, which can be easily pulverized. The crystal grains can be directly subjected to one-time jet pulverization to obtain particles with a D 90 of 15 μm or less that meet the formulation requirements.
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