abstract |
The subject matter herein relates to carbazole-containing amide, carbamate and urea derivatives of structural formula I, and pharmaceutically acceptable salts or hydrates thereof, wherein the variables R 1 , R 2 , R 3 , R 4 are correspondingly described , R 5 , R 6 , R 7 , A, D, E, G, J, L, M, Q, a and b. Also provided are pharmaceutical compositions containing a compound of formula I for the treatment of Cry-mediated diseases or disorders, such as diabetes, diabetes-related complications, Cushing's syndrome, NASH, NAFLD, asthma, and COPD. |