| abstract |
The invention relates to a small molecule reversible BTK inhibitor for treating rheumatoid arthritis, and particularly provides a compound which is a compound shown as a formula I or a stereoisomer, a geometric isomer, a tautomer, a nitrogen oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof. The inventor finds that the polysubstituted quinoline compound shown in the formula I or the derivative thereof can be used as a BTK inhibitor and has better activity when being used for treating rheumatoid arthritis. |