http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110003089-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-86 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-86 |
| filingDate | 2019-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110003089-B |
| titleOfInvention | 3-hydroxymethyl-9-substituted carbazole and preparation method thereof |
| abstract | The invention provides a preparation method of 3-hydroxymethyl-9-substituted carbazole. A mL of DMSO, B mol of paraformaldehyde, C mol of sodium ethoxide and D mL of absolute ethyl alcohol are sequentially added into a dry 100mL three-neck flask under the cooling of an ice salt bath, the mixture is stirred, after the solid is dissolved, an E mol of N-alkyl carbazole DMSO solution is quickly dropped, A: E = (100-300): 1, C: D =1:8, B: C: E =1:1.5:1, and the reaction is stopped by using a few drops of concentrated hydrochloric acid after 3min of reaction. Then adding distilled water, separating out solid, filtering, washing and drying to obtain the crude product. Recrystallizing the crude product with absolute ethyl alcohol to obtain the pure product of 3-hydroxymethyl-9-substituted carbazole. The method has the advantages of simple operation, short reaction time, high product purity, high yield, mild reaction conditions, safety and environmental protection, and has important significance for the synthesis and development of the compounds. |
| priorityDate | 2019-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 48.