http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110003083-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_03debaa92c4cb2a0b7a769e393ec86f5 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-584 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-42 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-42 |
| filingDate | 2019-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de8124f74d41de8055684c5537e2470f |
| publicationDate | 2019-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110003083-A |
| titleOfInvention | A kind of technological method of adopting Ir catalyst to prepare S-indoline-2-carboxylic acid |
| abstract | A process method for preparing S-indoline-2-carboxylic acid by using an Ir catalyst, which belongs to the technical field of pharmaceutical intermediates. In this method, in the reaction process of reducing indole-2-carboxylate to obtain S-indoline-2-carboxylic acid, a complex Ir-(S a , a novel chiral spirocyclic phosphine nitrogen ligand and iridium is used, S)-SIPHOX is used as a catalyst to realize the efficient asymmetric hydrogenation of indole-2-carboxylate to obtain the target product S-indoline-2-carboxylic acid. The advantages are that the asymmetric catalytic hydrogenation can be completed under normal pressure, the tolerance of functional groups is good, the efficiency is high, the enantioselectivity is excellent, the production process is greatly simplified, and the product of S-indoline-2-carboxylic acid is obtained. The yield and purity are much higher than the traditional process. The method has many advantages such as greatly improving yield, reducing cost, improving safety, saving energy, etc., and meets the requirements of modern chemical production of green reaction. |
| priorityDate | 2019-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 71.