http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109988561-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c34545d5608f375cb166f78353663169 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1044 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1029 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1007 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-6428 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-6447 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09K11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2019-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3feed531f50580cb32fa1189a0dce0c4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_27b26edb8d1ee5e6033da83bffae4d5d |
| publicationDate | 2019-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109988561-A |
| titleOfInvention | Imidazo[1,2-a]pyridine-based ratiometric pH fluorescent probe and preparation method and application thereof |
| abstract | The invention provides an imidazo[1,2-a]pyridine ratio-type pH fluorescent probe and a preparation method thereof, and the probe is used for the determination of extremely acidic pH changes in living cells and Escherichia coli. The preparation method is as follows: under the protection of inert gas, N,N-dimethylbenzaldehyde or its derivative, 4-chloroaniline and sodium bicarbonate are dissolved in methanol, and the crude product is obtained by heating and refluxing reaction; and 2-(4-methoxyphenyl)-7-methylimidazo[1,2-a]pyridine dissolved in N,N-dimethylformamide, using potassium tert-butoxide as basic reagent, heating Reflux reaction; obtained by silica gel column separation. The probe exhibits ratiometric fluorescence emission characteristics under extremely acidic conditions, and simultaneously possesses the advantages of high sensitivity to H + , good selectivity, and large Stokes shift. |
| priorityDate | 2019-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 53.