| abstract |
The invention provides a febuxostat controlled-release composition and a preparation method thereof. Specifically, the febuxostat controlled-release composition of the present invention contains an outer layer of at least one matrix-forming agent that swells in water, and after the composition is retained in the stomach for at least 4 hours, the tablet core swells to rupture the outer layer drug release. The composition provided by the invention can effectively reduce the peak value of drug concentration in plasma, prolong the action time of the effective drug, thereby reducing side effects and improving patient compliance. |