http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109970681-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d43ea4f6f6fbb9e854b9fc087dd20839 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B53-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B53-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-135 |
| filingDate | 2019-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_535724332277d657767ef07a5b52149b |
| publicationDate | 2019-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109970681-A |
| titleOfInvention | A kind of synthetic method of repaglinide |
| abstract | The invention discloses a method for synthesizing repaglinide, which belongs to the technical field of pharmaceutical synthesis. The method comprises the following steps: using ortho-halogenated benzaldehyde as a raw material, substituted by piperidine to obtain 2-piperidine-1-benzaldehyde compound 1, and then reacting with (R)-tert-butyl sulfinamide to obtain an imine compound 2, then react with 2-methyl-1-propylene Grignard reagent lithium chloride, obtain S-(+)-1-(2-piperidine phenyl)-3-methyl-n-butylamine compound 3 through reduction; Subsequent condensation with 4-carboxymethyl-2-ethoxybenzoate yields S-(+)-2-ethoxy-4-[N-{1-(2-piperidinephenyl)-3- Methyl-1-butyl}aminocarbonylmethyl]benzoate compound 4; finally, repaglinide 5 is obtained by hydrolysis. Compared with other processes, the invention has the characteristics of simple operation, easy availability of raw materials, high yield, low cost and environmental friendliness, and the product repaglinide has high optical purity and is suitable for industrial production. |
| priorityDate | 2019-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 201.