| abstract |
The invention belongs to the field of pharmacy and formulation, and relates to a pramipexole sustained-release pharmaceutical composition, a preparation method and application thereof. Specifically, the present invention relates to a pramipexole sustained-release pharmaceutical composition, comprising pramipexole or a pharmaceutically acceptable salt thereof and a sustained-release material, wherein the sustained-release material is composed of a neutral water-swellable polymer and anionic water Swellable polymer composition; wherein, calculated according to the weight percentage of the pharmaceutical composition: pramipexole or its pharmaceutically acceptable salt 0.05%-1%, neutral water-swellable polymer 80%-99%, and anionic water-swellable Polymer 1%-10%. The preparation of the present invention has better stability, less impurities and better safety. |