| abstract |
The present invention relates to the preparation of a series of chiral DOTA, D03A, D02A, DO1A, cyclamenine and their metal complexes, which show superior performance over previous DOTA-based compounds and thus have potential as platforms for diagnostic applications value. Chiral DOTAs display a high abundance of twisted tetragonal antiprism (TSA) geometries, favoring their use as potential MRI contrast agents, while their fast labeling properties under mild conditions make them useful as radiometal chelates Excellent candidate for mixtures. |