| abstract |
The present invention relates to a polypeptide derivative that promotes cell proliferation, a preparation method and application thereof. The polypeptide derivative has the following structure: Nap-FFGGYGSSSRRAPQT. The present invention also provides a preparation method of the above-mentioned polypeptide derivative. The polypeptide derivative adopts FMOC-solid phase synthesis method. The present invention also provides the use of the above-mentioned polypeptide derivatives in medicines for promoting cell proliferation. The invention is simple to synthesize, and can synthesize active self-assembled polypeptides by solid-phase synthesis, and the raw materials used are amino acids necessary for the human body every day; secondly, because of its self-assembly, it can be slowly released in the body, which significantly solves the problem of IGF- After injection, protein I is easily degraded by various proteases in the body, which leads to the problem of low retention rate in the body; most importantly, it can bind to the IGF-I protein receptor, which in turn can stimulate downstream signaling pathways, promote endothelial cell proliferation, and promote Vascular repair and regeneration. |