http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109956941-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-551 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-08 |
| filingDate | 2017-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109956941-B |
| titleOfInvention | A kind of simple preparation method of avibactam |
| abstract | The invention provides a simple preparation method of avibactam, which takes piperidin-5-keto-2S-formate II as a raw material, undergoes condensation reaction with O-protective group hydroxylamine hydrochloride, and then undergoes reduction, chiral Split, hydrolyze under alkaline conditions to obtain 5R-substituent oxyaminopiperidine-2S-formic acid V; then carry out cyclic ureation, acid chlorination and amidation with phosgene, solid phosgene or diphosgene "one-pot method" Reaction, through deprotection, sulfuric esterification, tetrabutylammonium salt formation to obtain {[(2S,5R)-2-carbamoyl-7-oxo-1,6-diazacyclo[3.2.1] Octane-6-yl]oxy}sulfonyl tetra-n-butylammonium salt VII, and finally obtain Avibactam I through ion exchange. The preparation route of the invention is simple, easy to operate, low in raw material price, low in cost, low in "three wastes" discharge, high in atom utilization rate, economical and environmentally friendly, and high in yield in each step, which is beneficial to the industrialized production of avibactam. |
| priorityDate | 2017-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 223.