http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109942826-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G81-00 |
| filingDate | 2019-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109942826-B |
| titleOfInvention | Redox-responsive hyperbranched chitosan and preparation method and application thereof |
| abstract | The invention provides a redox-responsive hyperbranched chitosan, and a preparation method and application thereof. The invention adopts a bifunctional reagent containing disulfide bonds to crosslink a low-molecular-weight hyperbranched polymer, and then chitin is grafted on a crosslinked hyperbranched polymer skeleton to prepare the redox-responsive hyperbranched poly (chitin) with the hyperbranched polymer skeleton containing disulfide bonds as a core and the chitin as a terminal group. The redox-responsive hyperbranched chitosan provided by the invention has a special hyperbranched structure, overcomes the structural limitation of the original linear chitosan, and has the environmental response characteristics of pH sensitive charge reversal and redox degradation due to the fact that the chitosan with pKa of about 6.5 at the periphery of the hyperbranched chitosan. The environment-responsive hyperbranched chitosan shows excellent biocompatibility and high-efficiency gene delivery performance, and has wide application prospect in the fields of gene therapy and gene editing. |
| priorityDate | 2019-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.