http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109939122-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7105 |
| filingDate | 2019-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109939122-B |
| titleOfInvention | Application of substances that regulate one-carbon metabolism and affect the stemness of cancer stem cells |
| abstract | The invention belongs to the field of biomedicine, in particular to the application of a substance that regulates one-carbon metabolism and affects the stemness of tumor stem cells in the preparation of products, a pharmaceutical composition and an in vitro non-therapeutic method for inhibiting the growth of cancer cells. The substance that suppresses and regulates one-carbon metabolism and affects the stemness of cancer stem cells is miRNA6778-5p shRNA or SHMT1 shRNA or modified miRNA6778-5p shRNA or modified SHMT1 shRNA, and the pharmaceutical composition can effectively inhibit SHMT1 gene expression and/or or protein activity to inhibit the growth of cancer cells; the multiple applications of the provided substance that regulates one-carbon metabolism and affects the stemness of cancer stem cells are helpful for the treatment of cancer, especially gastric cancer. |
| priorityDate | 2019-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 127.