http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109928975-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2017-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109928975-B |
| titleOfInvention | A kind of industrialized preparation method of ribociclib |
| abstract | The present invention relates to an industrialized preparation method of ribociclib. The method comprises: a condensation reaction of N,N-dimethyl-2,2-dihalogenated-4-cyano-n-butyramide (II) and a methylidene reagent (III) to prepare a compound of formula IV; and then make a compound of formula IV The compound and the compound of formula V are condensed to obtain the compound of formula VI; the compound VI and halocyclopentane undergo N-substitution reaction to obtain N,N-dimethyl-7-cyclopentyl-2-{5-[(4-PG substitution Piperazin-1-yl)pyridin-2-yl]}amino-7H-pyrrole[2,3-d]lopyrimidine-6-carboxamide (VIII), compound VIII is de-PG substituent to obtain ribociclib . The method of the invention has the advantages of cheap and easy-to-obtain raw materials, simple and convenient technological process, safe operation and low cost. |
| priorityDate | 2017-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 147.