http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109925314-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4535 |
| filingDate | 2018-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109925314-B |
| titleOfInvention | Raloxifene hydrochloride phospholipid complex solid dispersion and preparation thereof |
| abstract | The invention belongs to the technical field of medicines, and discloses a raloxifene hydrochloride phospholipid complex solid dispersion and a preparation method thereof. The solid dispersion of the raloxifene hydrochloride phospholipid complex consists of raloxifene hydrochloride, phospholipid and hydroxypropyl-beta-cyclodextrin. The solid dispersion of the raloxifene hydrochloride phospholipid complex is prepared by controlling the mass ratio of raloxifene hydrochloride to phospholipid to prepare a pharmaceutically acceptable raloxifene hydrochloride phospholipid complex, and further preparing the raloxifene hydrochloride phospholipid complex into the solid dispersion by taking hydroxypropyl-beta-cyclodextrin as a carrier: the preparation not only improves the in vitro dissolution and solubility of the raloxifene hydrochloride in the phospholipid compound, but also obviously improves the bioavailability of the raloxifene hydrochloride, and has certain drug forming property. The prepared raloxifene hydrochloride phospholipid complex solid dispersion is mixed with a pharmaceutically acceptable carrier to prepare a clinically acceptable preparation, and the preparation process is simple and feasible and is beneficial to industrial mass production. |
| priorityDate | 2018-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 48.