http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109912672-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-23 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-067 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-06 |
| filingDate | 2019-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109912672-B |
| titleOfInvention | Method for glycosylation of base by taking o-alkynyl phenol ether as leaving group |
| abstract | The invention discloses a method for constructing a nucleoside C-N glycosidic bond, which has the advantages of simple operation, mild condition and high reaction stereoselectivity and regioselectivity. A glycosylation product shown as a formula P is prepared by taking o-alkynyl phenol ether as a leaving group and carrying out glycosylation reaction on a glycosylation donor shown as a formula I and a glycosylation receptor shown as a formula S under the action of an accelerator in an inert gas environment in the presence of a drying agent, wherein RNH is a base compound, and Gly is glycosyl with one or more hydroxyl groups on a glycosyl ring protected by a protecting group. The glycosylation reaction condition of the invention is mild, the C-N glycosylation product can be obtained with better yield, and the glycosylation method for constructing the nucleoside bond is enriched. The o-alkynyl phenol ether glycosylation donor disclosed by the invention is stable, easy to store and widely used for various glycosylation reactions. The leaving group of the donor is an ether protecting group, and the protecting group operation can be carried out by being distinguished from a benzyl ether protecting group. |
| priorityDate | 2019-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 51.