http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109912605-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2019-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109912605-B |
| titleOfInvention | Purification method of pemetrexed intermediate |
| abstract | The invention provides a purification method of a pemetrexed intermediate, which comprises the following steps: A) dissolving a pemetrexed intermediate crude product in a solvent to obtain a pemetrexed intermediate crude product solution; B) and mixing the crude pemetrexed intermediate solution with trifluoroacetic acid to obtain the trifluoroacetate of the pemetrexed intermediate. The invention adds proper acid into a certain solvent at a certain temperature to form salt with the intermediate, thereby achieving the purpose of purifying the pemetrexed intermediate, reducing the impurity content in the intermediate and obtaining the high-purity pemetrexed intermediate. The intermediate is used for preparing the pemetrexed disodium raw material drug, so that the impurity residue in the raw material drug can be effectively reduced, and the pemetrexed disodium raw material drug with high purity and meeting the medicinal standard is obtained. The preparation method provided by the invention is simple to operate and is suitable for industrial production. Meanwhile, the trifluoroacetic acid used in the method can not introduce genotoxic impurities, so that the method is safer. |
| priorityDate | 2019-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 560.