http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109912570-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3adbf5f940d3e0e19c55b7ab783c2a06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
| filingDate | 2019-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94c75a44c7fa2b709df754857e2baf53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_627d125efaa12d8e4ec909615847242a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d75bf591f9a19a4d4fdee02790c03224 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a04121cd00260bddce20379ae64c3680 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da58bd691ca5804d3e6f688c2adc51d3 |
| publicationDate | 2019-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109912570-A |
| titleOfInvention | A kind of preparation method of argatroban intermediate amidate |
| abstract | The present invention relates to a kind of preparation method of argatroban intermediate amidate. , 4R)-4-methyl-2-piperidine formate, 3-methyl-8-quinoline sulfonyl chloride are substrate preparation (2R, 4R)-1-[N G -nitro-N 2- (3-methyl-8-quinolinesulfonyl)-L-arginyl]-4-methyl-2-piperidinecarboxylate ethyl ester. The beneficial effects of the invention are as follows: the production process eliminates the harsh conditions of water, avoids the occurrence of zero batch numbers, and the reaction is simplified into a one-step reaction operation, the post-processing process is simple and easy to operate, the solvent is easy to recycle, and the reduction of temperature makes the reaction The process is mild, the HPLC purity is increased by 14%, and the yield is increased by 13%, which is more realized by industrialization. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111961114-A |
| priorityDate | 2019-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.