http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109912519-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D243-08 |
| filingDate | 2019-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109912519-B |
| titleOfInvention | A kind of synthetic method of Suwo Leisheng intermediate |
| abstract | The present invention provides a method for synthesizing Suvorexan intermediate (5S)-hexahydro-5-methyl-1H-1,4-diazepine-1-carboxylate tert-butyl ester, comprising the following steps: (1) compound Suvor-1 reacts with red aluminum solution to obtain compound Suvor-2; (2) compound Suvor-2 reacts with 4,4-dimethoxy-2-butanone to obtain Suvor-3; (3) ) compound Suvor-3 reacts with methanesulfonic acid to obtain compound Suvor-4; (4) compound Suvor-4 reacts with di-tert-butyl dicarbonate to obtain compound Suvor-5; (5) compound Suvor-5 reacts with hydrogen, Obtain Suvorexan intermediates. The method has simple reaction, cheap and easy-to-obtain starting materials, mild reaction conditions, and high production safety; in addition, the method has few reaction steps, high reaction yield, and low production cost; Induced synthesis, the target product obtained after ring closure has high purity, less enantiomeric impurities, and ee% is greater than 97%, which is suitable for commercial scale production. |
| priorityDate | 2019-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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