| abstract |
The invention provides a preparation method of dexmedetomidine and its hydrochloride. Specifically, the present invention uses the carbon-carbon hydrogenation reduction catalyst and the composition of (R,S)-Duanphos as the catalyst to carry out chiral catalytic reduction of the double bond, and directly obtains dexmedetomidine with an enantiomeric excess percentage of 99.9%. Certainly, the preparation method of the present invention has a short synthetic route, the product does not need chiral resolution, and the yield is high. |